The Brazilian star arrived at the club from Ajax last summer in a blockbuster deal worth £86million, however the 23-year-old hasn't lived up to that price tag since his arrival.
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Antony has made 31 appearances for Man United so far, scoring seven in total, but with just three coming in the Premier League.
In addition, the winger has contributed just one assist for Erik ten Hag's side, a total which is lower than many would have hoped from a huge new signing.
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Agbonlahor has been a vocal critic of Antony's since the early stages of the season and according to the ex-Aston Villa star, the Brazilian has done little to convince him that his opinion is wrong.
Speaking on The Sports Breakfast, Agbonlahor said: "When I watch Antony I look at his stats for starters. He's played 16 Premier League games, three goals and zero assists.
"He's got zero assists because of the way he plays. I've watched him all season, I watched him last night against Brentford and he gets the ball and knows he can't beat the full-back on the outside, so he pretends to go on the outside, goes inside and gives it away.
"If you're a striker then you're frustrated. Andy Cole came out and said that if he was a striker in the team he'd be so frustrated because you're not going to get chances.
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"I would swap him, any day of the week, for Antonio Valencia.
"His first season at Manchester United he got seven goals and 13 assists. The season after, six goals and 16 assists, then he went to right-back.
"That's a winger who used to get the ball, a little step-over, pace and power and clip it in. Strikers knew when it was coming in.
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"Antony gets it and does his little tricks. Yesterday, there was one incident where he took himself on - he didn't take the defender on, he took himself on!
"He takes the ball, does a little shimmy and the defender is just stood there, like 'go on then, take me on'."
Ally McCoist added: "It's difficult not to agree with what Gabby said about Antony because you're looking for more.
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"The only thing you could say is that he's still early in his career at Manchester United - you'd hope there's improvement in him.
"Manchester United need to get more from them and I also think they need to get more from the other side from Sancho.
"I don't think they're getting enough in those areas."