Returning from the international break with just two points on the board, Milan are marginally ahead of their promoted opponents, who only have one goal and one point to their name so far.
Match preview
With speculation already growing as to his possible successor - former boss Max Allegri and Thomas Tuchel apparently among the leading candidates - Milan's new head coach Paulo Fonseca will desperate to secure his first competitive win on Saturday evening.
His time in the hotseat at San Siro has certainly started below expectations, as having drawn 2-2 with Torino on Serie A's opening matchday - after trailing by two goals until the 89th minute - the Rossoneri were then beaten by newly promoted Parma.
After letting a lead slip against Lazio last time out, only a stunning breakaway goal created by Tammy Abraham and goalscorer Rafael Leao - the latter of whom had been dramatically dropped alongside fellow star Theo Hernandez - saw Milan avoid defeat in the capital.
Concerns certainly remain about their brittle back four, and stretching back to the end of Stefano Pioli's reign, the Lombardy club have conceded at least two goals in each of their last five matches, at an ugly average of 2.4 per game.
Should they fail to pick up three points this weekend, the Rossoneri would fail to win any of their first four Serie A fixtures for only the second time in the last 65 years - and the first time this century.
Ahead of hosting Liverpool in the Champions League next week, a more assured performance is required on Saturday night at San Siro, where Milan have lost just one of their 13 previous home games against Venezia in Serie A.
That sole away win for the Venetians was way back in 1942, while their last league victory over Milan anywhere came some 24 years ago.
Yet to find their feet since gaining promotion through the Serie B playoffs last season, Venezia have taken just one point from three top-flight fixtures so far, in addition to crashing out of the Coppa Italia.
Beaten by their old boss last time out, the Lagunari lost to a late goal against Paolo Vanoli's Torino - again failing to find the net.
Magnus Andersen actually put Venezia in front in their first-day clash with Lazio, which they ultimately lost 3-1, but since then no more goals have been scored by the Arancioneroverdi.
Head coach Eusebio Di Francesco has a tough task on his hands to turn things around after a disappointing summer in the transfer market, but Milan's leaky defence may at least help his side end their worrying goal drought.
AC Milan Serie A form:
Venezia Serie A form:
Venezia form (all competitions):
Team News
Having been reunited with his former Roma colleague at the very end of the transfer window, Milan boss Paulo Fonseca is set to hand Tammy Abraham his first start on Saturday, as first-choice striker Alvaro Morata only returned to full training on Wednesday.
While the Spain star is back from a thigh injury, Ismael Bennacer and Alessandro Florenzi are both out for the long term, and centre-back Malick Thiaw is struggling with an ankle sprain.
Though he was benched against Lazio, Rafael Leao is likely to regain his place this weekend: since the start of last season, he is the only player to have reached double figures for both goals and assists in Serie A (10 of each).
Venezia's main marksman, Joel Pohjanpalo, returned to fitness just before the break, and now the Finnish striker will seek his first top-flight goal of the season after scoring 22 times in Serie B last term.
Ex-Inter Milan forward Gaetano Oristanio returns to San Siro and is likely to start in support of Pohjanpalo, at the apex of a 3-4-2-1 formation.
With USA international Gianluca Busio using the last fortnight to recover from injury, Eusebio Di Francesco could have a full squad to choose from.
AC Milan possible starting lineup:
Maignan; Calabria, Tomori, Pavlovic, Hernandez; Fofana, Reijnders; Pulisic, Loftus-Cheek, Leao; Abraham
Venezia possible starting lineup:
Joronen; Idzes, Svoboda, Sverko; Candela, Duncan, Nicolussi Caviglia, Zampano; Oristanio, Ellertsson; Pohjanpalo
We say: AC Milan 3-1 Venezia
Already nearing must-win territory for Paulo Fonseca, his Milan side must surely see off a Venezia team that look set for a long season of struggle.
The visitors lack bite in the final third, and their shaky defence can be exploited by the guile and speed of Rafael Leao, Christian Pulisic and co.