After beating Cacereno 1-0 on Tuesday to qualify for the Copa del Rey Round of 16, Real Madrid are set to face Villarreal at the Estadio de la Ceramica on Saturday.
Rodrygo Goes netted in the second half to seal qualification for Los Blancos, who currently sit top of the LaLiga Santander table along with title contenders Barcelona.
As for Villarreal, Quique Setien's side cruised past Cartagena with a 5-1 Copa del Rey victory on Tuesday ahead of the duel against Carlo Ancelotti's men.
Villarreal vs Real Madrid predicted line-ups
Villarreal will take to the Estadio de la Ceramica pitch without Giovani Lo Celso, who remains sidelined through injury. Meanwhile, Francis Coquelin could also miss out on the match due to a knock.
Ancelotti may not have starting right-back Dani Carvajal at his disposal through injury, while Mariano Diaz and Alvaro Odriozola are injury doubts ahead of Saturday's clash.
Villarreal's predicted line-up (4-3-3): Geronimo Rulli; Juan Foyth, Raul Albiol, Pau Torres, Alfonso Pedraza; Etienne Capoue, Dani Parejo, Manu Trigueros; Samu Chukwueze, Gerard Moreno, Arnaut Danjuma.
Real Madrid's predicted line-up (4-3-3): Thibaut Courtois; Lucas Vazquez, Eder Militao, David Alaba, Ferland Mendy; Luka Modric, Aurelien Tchouameni, Toni Kroos; Fede Valverde, Karim Benzema, Vinicius Junior.
When does Villarreal vs Real Madrid start?
This Saturday's match between Villarreal and Real Madrid kicks off at 16:15 CET, the local time in Spain. For those living in the UK, you can tune in at 15:15 BST. For American viewers, the match will begin at 10:15 ET/ 07:15 PT.
Where to watch Villarreal vs Real Madrid?
The LaLiga Santander match between Villarreal and Real Madrid will take place at the Estadio de la Ceramica on Saturday, January 7. For those living in the UK you can watch the game on LaLiga TV, while viewers in the USA can tune in via ESPN+ and ESPN Deportes.