David Moyes' side have won their last four games in Europe which is their longest-ever run in UEFA competitions.
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The Hammers beat Wolves last time out in the Premier League to pick up a crucial win following three league games without victory.
They now come up against Anderlecht who are behind the London side in second place in Group B.
However, the Purple and White are only 10th in the Belgian Pro League having made a disappointing start to the campaign.
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Anderlecht vs West Ham: How to follow
This Conference League clash will take place on Thursday, October 6.
The game at Lotto Park in Belgium will kick off at 5:45pm.
You can watch the match live on BT Sport 2 with coverage beginning at 5:15pm.
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BT Sport customers will also have access to a live stream online via the BT Sport app or website.
talkSPORT will have updates throughout the game.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Anderlecht vs West Ham: Team news
Former Spurs defender Jan Vertonghen is expected to be a part of the Anderlecht back three.
However, the Belgian side will remain without Marco Kana and Adrien Trebel.
Maxwel Cornet would have been likely to start for West Ham but after being substituted in the first half at the weekend, he is now a doubt.
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Full-back Ben Johnson is in contention to return after recovering from injury.
Anderlecht vs West Ham: What's been said?
Hammers boss Moyes is happy with his squad ahead of the match but is wary of a challenging game this evening.
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He said: "I think we wanted a stronger squad of players so we could come to Europe and play a really strong team. We've just about got everyone back.
"I wouldn't in any way disrespect Anderlecht in any way at all. It's incredibly tough to do, come away and get results.
"They will want to win, see a chance to try and go above us. At the moment, we look like the teams with the most points."
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Anderlecht vs West Ham: Match facts
West Ham have scored six goals across their first two matches in the UEFA Conference League this season, with all six being scored by different players - no side have more different goal scorers in the competition this season.
Including qualifiers, West Ham United have won each of their last four games in UEFA competitions, their longest ever winning streak on the European stage; the Hammers have scored three goals in each of their last four games.
Including qualifiers, RSC Anderlecht have lost just one of their last six games in the UEFA Conference League (W4 D1), however, their only defeat during that period also came at home (0-1 v Young Boys).
RSC Anderlecht have won just one of their last 13 games against English opposition in European competitions (D3 L9), however, their only win during that period also came at their home stadium (2-1 v Tottenham Hotspur in October 2015).
This will be just the second ever meeting between RSC Anderlecht and West Ham United on the European stage, and their first since the 1976 Cup Winners' Cup final, when Anderlecht defeated West Ham 4-2 to lift the trophy.