Inter Milan vs. Atletico (Tuesday, 8.00pm)
In perhaps the pick of this year's last-16 ties, Inter Milan meet Atletico Madrid, with the first leg of their Champions League clash taking place at San Siro on Tuesday.
Last season's runners-up, Inter are flying high at the top of Serie A, while Atleti stormed through the group stage to reach the knockout rounds once again.
We say: Inter Milan 1-1 Atletico Madrid
Inter and Atletico can both call upon plenty of European experience, grit and nous, so a tight contest is to be expected. The two sides have scored freely this term, though, and an abundance of attacking talent will surely have their say.
PSV vs. Dortmund (Tuesday, 8.00pm)
Runaway Eredivisie leaders PSV Eindhoven put themselves to the test on Tuesday, as Borussia Dortmund arrive at Philips Stadion for the first leg of their last-16 tie in UEFA's top club competition.
PSV's first Champions League knockout game for eight years will see the Dutch side meet opponents that emerged unscathed from this season's 'Group of Death'.
We say: PSV Eindhoven 2-1 Borussia Dortmund
Goals are almost assured at Philips Stadion, where PSV are often relentless and can pummel their opponents into submission. Dortmund's group-stage showing, however, suggests that they can take the fight to their hosts, staying in the contest ahead of next month's game in Germany.