For the majority of the season, Gary O'Neil has deployed a back three, that strategy leading to numerous strong performances and Wolves scoring in 17 successive matches in all competitions.
However, despite also collecting four points against Burnley and Nottingham Forest, O'Neil appears to have switched to a 4-2-3-1 formation.
Jean-Ricner Bellegarde is the beneficiary with an opportunity in the final third, either on the right flank or in a central role behind Matheus Cunha.
There is also a change between the sticks with Daniel Bentley replacing first-choice goalkeeper Jose Sa, who is presumably injured with Tom King being named on the substitutes' bench.
Meanwhile, West Ham boss David Moyes has opted to make just the one alteration to the team that defeated Freiburg in the Europa League on Thursday night.
Kurt Zouma, who is yet to play a single European fixture all season, comes back into the centre of defence to replace Konstantinos Mavropanos.
Veteran goalkeeper Lukasz Fabianski continues his run of appearances, despite Alphonse Areola being fit enough to feature on the bench.
West Ham United: Fabianski; Coufal, Zouma, Aguerd, Emerson; Alvarez, Ward-Prowse, Soucek; Kudus, Bowen, Paqueta
Subs: Areola, Ogbonna, Mavropanos, Kehrer, Fornals, Ings, Cresswell, Benrahma, Mubama
Wolverhampton Wanderers: Bentley; Semedo, Dawson, Kilman, Toti; Gomes, Lemina; Bellegarde, Sarabia, Hwang; Cunha
Subs: King, Doherty, Ait-Nouri, S.Bueno, Traore, Silva, H.Bueno, Kalajdzic, Doyle