In the build-up to the match at Molineux, head coach Gary O'Neil remained coy over the fitness of Jean-Ricner Bellegarde, Pedro Neto and Matheus Cunha, hinting that the latter may return to the squad after making an appearance in full training after a hamstring injury.
However, all three players miss out for the showdown with the Sky Blues, O'Neil instead making just the two alterations courtesy of Bellegarde's and Neto's injuries last weekend.
Toti Gomes returns to the back three - O'Neil moving away from the defensive four that he used against Fulham - and Tommy Doyle is brought into the midfield.
With Craig Dawson failing to recover from a groin issue, Santiago Bueno retains his place in the defence, while Nathan Fraser leads the line for the second game in succession.
Wolves have as many as five players on the substitutes' bench who have never started a first-team game for the club.
Meanwhile, Coventry boss Mark Robins has also made two changes to the side that started the 2-1 victory over Watford.
Liam Kelly and Victor Torp each drop to the substitutes' bench, the latter having passed a fitness test having seemingly sustained a hamstring issue at Vicarage Road.
With Josh Eccles moving into a central-midfield position, Milan van Ewijk returns at right wing-back, while Ben Sheaf is recalled after making his return from a near six-week absence through injury versus the Hornets.
Wolverhampton Wanderers: Sa; S.Bueno, Kilman, Toti; Semedo, Gomes, M.Lemina, Doyle, Ait-Nouri; Sarabia; Fraser
Subs: Bentley, Traore, Doherty, N.Lemina, H.Bueno, Holman, Barnett, Chirewa, Chiwome
Coventry City: Collins; Thomas, Latibeaudiere, Kitching; Van Ewijk, Eccles, Sheaf, Bidwell; Palmer; Simms, Wright
Subs: Wilson, Binks, Dasilva, Torp, Kelly, Andrews, O'Hare, Godden, Tavares