Gary O'Neil brings back Craig Dawson, Mario Lemina and Pedro Neto, the former and latter having not been overly risked in recent games and Lemina having only recently returned to the club after the passing of his father.
Santiago Bueno has dropped out of the back three to accommodate the return of Dawson, while Joe Hodge and Jean-Ricner Bellegarde also only feature on the substitutes' bench.
Yerson Mosquera is selected as a substitute despite being heavily linked with a loan switch to Villarreal, with Nathan Fraser hopeful of a Premier League bow after impressing versus Brentford in the FA Cup.
Meanwhile, Brighton are in action for the first time in 16 days, and Roberto De Zerbi has opted to make three alterations of his own from the team that recorded a 4-2 triumph in the FA Cup over Stoke City..
Goalkeeper Jason Steele has been preferred to Bart Verbruggen between the sticks, while there are also starts for James Milner and Danny Welbeck.
Although Welbeck represents a straight alternative to Ewan Ferguson, Milner takes the spot of Jakub Moder, who was deployed at left wing-back last time out.
Milner will either be used as a straight replacement at wing-back in a 3-4-3, or used as a central midfielder in a 4-3-3 formation.
Brighton & Hove Albion: Steele; Hinshelwood, Van Hecke, Dunk, Estupinan; Gilmour, Milner, Gross; Buonanotte, Welbeck, Pedro
Subs: Verbruggen, Lamptey, Webster, Lallana, Moder, Baleba, Ferguson, Peupion, Baker, Boaitey
Wolverhampton Wanderers: Sa; Dawson, Kilman, Gomes; Semedo, Lemina, Doyle, Doherty; Sarabia, Cunha, Neto
Subs: Bentley, S.Bueno, Mosquera, H.Bueno, Bellegarde, Hodge, Griffiths, Chirewa, Fraser