Los Blancos will enter the contest off the back of a 2-0 win over Granada, while Real Betis were held to a goalless draw by Almeria in their last league match, and here Sports Mole rounds up the team news.
REAL BETIS vs. REAL MADRID
REAL BETIS
Out: Hector Bellerin (suspended), Nabil Fekir (muscle), William Carvalho (hamstring), Claudio Bravo (hamstring), Youssouf Sabaly (knee), Marc Bartra (Achilles)
Doubtful: Rodri (muscle)
Sports Mole's predicted XI: Silva; Ruibal, Pezzella, Riad, Abner; Rodriguez, Roca; Diao, Isco, Perez; Willian Jose
REAL MADRID
Out: Dani Carvajal (calf), Vinicius Junior (thigh), Eduardo Camavinga (knee), Arda Guler (muscle), Aurelien Tchouameni (foot), Eder Militao (knee), Thibaut Courtois (knee)
Doubtful: Luka Modric (thigh),
Sports Mole's predicted XI: Kepa; Vazquez, Rudiger, Alaba, Mendy; Valverde, Kroos, Modric; Bellingham; Rodrygo, Diaz
For data analysis of the most likely results, scorelines and more for this match please click here.