The Ukraine international has found himself in and out of the starting lineup this season, but he gets the nod over Cole Palmer for the fixture at Stamford Bridge.
Head coach Mauricio Pochettino makes a total of four changes, two others enforced due to the suspensions of Reece James and Marc Cucurella.
Lesley Ugochukwu also drops out of midfield, with Axel Disasi, Levi Colwill and Moises Caicedo the players coming into the team.
Palmer features among the replacements, but Ugochukwu does not, with the only recognised defensive-minded player on the substitutes' bench being youngster Alfie Gilchrist.
Meanwhile, there are as many as five different Brighton players in the starting lineup in comparison to the side that started the 3-2 victory over Nottingham Forest last weekend.
Lewis Dunk is suspended, Tariq Lamptey and Ansu Fati are injured, and Bart Verbruggen and Pascal Gross are only named among the substitutes.
Goalkeeper Jason Steele returns between the sticks, while Igor Julio and Jack Hinshelwood take their place in the defence.
Carlos Baleba is named in midfield, with Facundo Buonanotte also being provided with an opportunity in the final third.
Chelsea: Sanchez; Disasi, Silva, Badiashile, Colwill; Gallagher, Caicedo, Fernandez; Sterling, Jackson, Mudryk
Subs: Bergstrom, Petrovic, Gilchrist, Maatsen, Matos, Madueke, Palmer, Broja, Washington
Brighton & Hove Albion: Steele; Veltman, Van Hecke, Igor, Hinshelwood; Gilmour, Baleba, Lallana; Buonanotte, Ferguson, Adingra
Subs: Verburggen, Milner, Kavanagh, Moder, Gross, Mitoma, Pedro, O'Mahony, Baker-Boaitey