The Red Devils beat Barcelona 4-3 in the playoffs but enter the contest on the back of being embarrassed 7-0 by Liverpool, while Los Verdiblancos beat Roma, HJK Helsinki and Ludogorets to first place in Group C, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER UNITED vs. REAL BETIS
MANCHESTER UNITED
Out: Anthony Martial (hip), Donny van de Beek (knee), Christian Eriksen (ankle), Marcel Sabitzer (unspecified)
Doubtful: Victor Lindelof (unspecified), Casemiro (unspecified)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Maguire, Martinez, Malacia; Fred, McTominay; Sancho, Fernandes, Garnacho; Rashford
REAL BETIS
Out: Nabil Fekir (knee), Juan Cruz (muscle)
Doubtful: Sergio Canales (quadriceps)
Sports Mole's predicted XI: Bravo; Sabaly, Felipe, Pezzella, Miranda; Carvalho, Rodriguez; Canales, Rodri, Perez; Iglesias
For data analysis of the most likely results, scorelines and more for this match please click here.