In the absence of the injured Rasmus Hojlund, manager Erik ten Hag has turned to 19-year-old Forson to join Marcus Rashford, Bruno Fernandes and Alejandro Garnacho in attack.
Academy graduate Forson steps up to start his first senior match and make just his second top-flight appearance, three-and-a-half weeks after coming on as a late substitute against Wolverhampton Wanderers.
Ten Hag has made just two changes to the Red Devils side that beat Luton Town 2-1 last weekend, with the only other alternation being the return of Victor Lindelof, who replaces the injured Luke Shaw at left-back.
Harry Maguire and Raphael Varane retain their places in the heart of the defence, protecting Andre Onana between the sticks, as Diogo Dalot continues to operate at right-back, while Kobbie Mainoo and Casemiro links arms once again in centre-midfield.
As for Fulham, Marco Silva has made a total of six changes to the lineup that began the 2-1 defeat at home to Aston Villa last time out, with Issa Diop, Tim Ream, Tom Cairney, Joao Palhinha, Bobby De Cordova-Reid and Willian all making way.
Ex-Manchester City youngster Tosin Adarabioyo and Calvin Bassey are both recalled to start at centre-back at the expense of Diop and Ream, joining Timothy Castagne and Antonee Robinson in the back four.
Palhinha, who is serving a two-match suspension due to an accumulation of yellow, and Cairney are both replaced in midfield by Harrison Reed - captaining the Cottagers - and Sasa Lukic.
In attack, former Man United man Andreas Pereira and in-form striker Rodrigo Muniz retain their places, but both Harry Wilson and Alex Iwobi come in for De Cordova-Reid and Willian to presumably play on the flanks.
Manchester United: Onana; Dalot, Varane, Maguire, Lindelof; Casemiro, Mainoo; Garnacho, Fernandes, Forson; Rashford
Subs: Bayindir, Evans, Kambwala, McTominay, Amrabat, Collyer, Eriksen, Amad, Antony
Fulham: Leno; Castagne, Tosin, Bassey, Robinson; Reed, Lukic; Wilson, Pereira, Iwobi; Muniz
Subs: Rodak, Ream, Diop, Tete, Bello-Toure, Cairney, De Cordova-Reid, Traore, Broja