On Tuesday evening, the pair were each introduced as substitutes during the EFL Cup tie against Newcastle United, helping the Blues to a 1-1 draw before prevailing on penalties.
Seemingly suitably impressed by their impact, head coach Mauricio Pochettino has included both players in his first XI at Molineux, making a total of three changes.
As well as the right-back and central forward, midfielder Lesley Ugochukwu returns from injury to replace Moises Caicedo, who does not feature in the squad.
Benoit Badiashile and Enzo Fernandez are also not named in the team, but Romeo Lavia is selected on the substitutes' bench for the first time after recovering from an ankle injury.
Meanwhile, Gary O'Neil has made two alterations and reverted to a back three after last weekend's 3-0 defeat at West Ham United.
Goalkeeper Jose Sa is in a position to return from a back injury, while Rayan Ait-Nouri is recalled after showing that he is over an ankle injury with a substitute outing at the London Stadium.
Daniel Bentley and Jean-Ricner Bellegarde have dropped out of the team, Bellegarde not even featuring in the squad alongside Fabio Silva.
Pedro Neto is also a notable absentee having been provided with a few more days to build his fitness after a hamstring injury.
Wolverhampton Wanderers: Sa; Semedo, Kilman, Dawson, Toti, Ait-Nouri; Gomes, Lemina; Sarabia; Hwang, Cunha
Subs: Bentley, Doherty, S.Bueno, H.Bueno, Kalajdzic, Doyle, Barnett, Chirewa, Hesketh
Chelsea: Petrovic; Gusto, Disasi, Silva, Colwill; Ugochukwu, Gallagher; Sterling, Palmer, Jackson; Broja
Subs: Bettinelli, Bergstrom, Badiashile, Maatsen, Lavia, Matos, Madueke, Mudryk, Nkunku