With both sides suffering defeat in their opening Group A fixtures, they are targeting maximum points at the Al Thumama Stadium to remain in the competition.
Senegal midfielder Cheikhou Kouyate has been ruled out of the tournament through injury, resulting in the more attack-minded Diedhiou being drafted into the side behind Boulaye Dia.
Aliou Cisse has also handed a start to Ismail Jakobs in the centre of defence, but goalkeeper Edouard Mendy, as expected, keeps his spot between the sticks despite making two mistakes against Netherlands.
However, Qatar boss Felix Sanchez has opted to make a change in goal with Meshaal Barsham being preferred to Saad Al Sheeb.
Ismaeel Mohammad is also handed an opportunity in the back three, while Assim Madibo is brought into the centre of midfield.
Qatar: Barsham; Ro-Ro, Mohammad, Khoukhi, Hassan, Ahmed; Al-Haydos, Boudiaf, Madibo; Abdulla, Afif
Senegal: Mendy; Sabaly, Koulibaly, Jakobs, Diallo; Gueye, Mendy; Diatta, Diedhiou, Sarr; Dia