Xavi's side are currently third in the table, eight points behind the leaders Girona, while a disappointing campaign has left Villarreal down in 14th, and here Sports Mole rounds up the team news.
BARCELONA vs. VILLARREAL
BARCELONA
Out: Andreas Christensen (calf), Raphinha (thigh), Inigo Martinez (muscle), Marcos Alonso (back), Gavi (knee), Marc-Andre ter Stegen (back), Alejandro Balde (thigh)
Doubtful: Ronald Araujo (knee)
Sports Mole's predicted XI: Pena; Roberto, Araujo, Kounde, Cancelo; Pedri, F de Jong, Gundogan; Torres, Lewandowski, Yamal
VILLARREAL
Out: Pepe Reina (suspended), Alfonso Pedraza (ankle), Ramon Terrats (knee), Dani Parejo (knee), Raul Albiol (hamstring), Juan Foyth (muscle), Yeremy Pino (knee), Denis Suarez (thigh)
Doubtful: None
Sports Mole's predicted XI: Jorgensen; Femenia, Bailly, Cuenca, A Moreno; Akhomach, Comesana, Coquelin, Baena; G Moreno, Sorloth
For data analysis of the most likely results, scorelines and more for this match please click here.