The hosts, meanwhile, must beat Jurgen Klopp's side in order to remain in the competition, as they trail the 2018-19 champions by six points with only two games remaining in Group A.
Here, Sports Mole rounds up all of the latest team news ahead of the huge clash at the Johann Cruyff Arena.
AJAX vs. LIVERPOOL
AJAX
Out: Ahmetcan Kaplan (knee)
Doubtful: Devyne Rensch (knock), Kenneth Taylor (knock), Mohamed Ihattaren (fitness)
Sports Mole's predicted XI: Pasveer; Sanchez, Timber, Bassey, Blind; Klaassen, Alvarez, Berghuis; Tadic, Kudus, Bergwijn
LIVERPOOL
Out: Joel Matip, Diogo Jota (both calf), Luis Diaz (knee), Arthur (muscle), Naby Keita, Alex Oxlade-Chamberlain (both unregistered)
Doubtful: Darwin Nunez (hamstring), Thiago Alcantara (ear infection), Ibrahima Konate (muscle)
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Henderson, Thiago; Elliott, Firmino, Nunez; Salah
For data analysis of the most likely results, scorelines and more for this match please click here.