Como vs. Bologna (Saturday, 2.00pm)
Como finally return home on Saturday afternoon, as they welcome Bologna to Stadio Giuseppe Sinigaglia, with both teams still seeking a first Serie A win of the season.
The hosts have played their first four games of the campaign on the road while their stadium was brought up to top-flight standards; now, Champions League-bound opponents visit their lakeside headquarters.
We say: Como 0-1 Bologna
With only three goals between them so far, neither side has been able to replicate last season's form in the final third, so one moment of magic - or madness - could decide the outcome.
Vincenzo Italiano's greater experience at the top level could see Cesc Fabregas and co defeated again, leaving cash-rich Como rock-bottom of Serie A.
Empoli vs. Juventus (Saturday, 5.00pm)
Two unbeaten teams meet at Stadio Castellani on Saturday evening, as Empoli play host to Serie A giants Juventus.
While Juve have made an impressive start to life under new management - and are yet to concede a single goal - the Tuscan club are surprisingly thriving at the start of their 2024-25 campaign.
We say: Empoli 0-2 Juventus
New-look Juventus should resume normal service this weekend, seeing off Empoli and keeping the pressure on likely title rivals Inter. With more of their summer acquisitions now fit and fully integrated, the visitors' squad is quite formidable.
AC Milan vs. Venezia (Saturday, 7.45pm)
Still seeking their first win of the new Serie A season, AC Milan will be under pressure to produce three points on Saturday, when they welcome Venezia to San Siro.
Returning from the international break with just two points on the board, Milan are marginally ahead of their promoted opponents, who only have one goal and one point to their name so far.
We say: AC Milan 3-1 Venezia
Already nearing must-win territory for Paulo Fonseca, his Milan side will surely see off a Venezia team that look set for a long season of struggle.
The visitors lack bite in the final third, and their shaky defence can be exploited by the guile and speed of Rafa Leao, Christian Pulisic and co.