The defending champions hold a 3-1 advantage over their fourth-tier opponents ahead of the match at Morumbi.
Match preview
There have been times during this campaign when Sao Paulo have looked out of form, putting together winless or losing runs on more than one occasion.
However, with the season now in full flow, Tricolor Paulista have managed to put together an eight-match unbeaten streak in all competitions.
Just four of those games have been in Serie A, Sao Paulo collecting 10 points from a possible 12 to move into fifth position in the table.
Sao Paulo have also not lost in their last four games in the Copa Libertadores, while also putting themselves in line to progress in the Copa do Brasil.
At one stage in the first leg, Luis Zubeldia's side found themselves in trouble, trailing the minnows by a 1-0 scoreline with 35 minute gone.
Aguia de Maraba were down to 10 men, though, and that ultimately proved pivotal as Sao Paulo came through with a 3-1 victory.
Regardless of what materialises on Thursday evening, the visitors will be satisfied to savour the opportunity to face a team of Sao Paulo's reputation.
Victories have already been recorded over Cortibia and Capital to reach this stage, with their priorities realistically needing to switch to life in Serie A.
Mathaus Sodre's team have failed to win any of their last seven matches in the fourth tier, leaving them down in bottom spot in Group Two of the First Phase.
Sao Paulo form (all competitions):
W
D
W
W
W
D
Aguia de Maraba form (in all competitions):