The Senegalese winger stepped out onto the Anfield turf aiming to score for the ninth game in a row against the Eagles, which would have also taken him up to 100 strikes in red.
Despite a relatively slow start to the game, Mane drew first blood in the 43rd minute of the contest, as the former Southampton man was on hand to hammer home a rebound after Vicente Guaita had saved Mohamed Salah's header.
Mane's strike on Saturday has seen him become the first player ever to score in nine consecutive Premier League games against a single opponent, while he has also become the 18th player to net 100 goals for Liverpool.
The 29-year-old had witnessed his teammate Salah hit a century of goals for the Merseyside giants in last week's win against Leeds United, and he now boasts 13 goals from 14 league games against Palace.