The Three Lions slipped to a disappointing 1-0 defeat to Denmark on Wednesday evening at Wembley as Christian Eriksen marked his 100th game with a goal from the spot.
Harry Maguire's red card within 31 minutes changed the complexion of the Nations League qualifier completely, with the 10 men of the Three Lions looking decidedly less potent than they did against Belgium last Sunday.
Aston Villa captain Jack Grealish remained on the bench for both games, meaning he has recorded just 14 minutes of competitive action for his country.
That was in last month's 0-0 draw with Denmark, with Grealish then starting last week's match against Wales - a fixture which, however, was only a friendly.
The 25-year-old was man of the match in the friendly against Ryan Giggs' side and Arsenal legend Ian Wright was left bemused by Gareth Southgate's decision.
"I'd probably be disappointed if I was him seeing different people getting warmed up to come on," Wright told ITV. "And you cannot blame him for trying to bring Calvert-Lewin on with his form.
"Jadon Sancho with the form we know that he can show.
"I would have liked to have seen him come on. He brought Jordan Henderson on.
"Fine! But the fact is, bring him on. We needed some creativity in the middle - He was MOTM against Wales. He sat out two games.
"You need someone who runs with the ball, passes the ball through. He's not afraid in any situation on the pitch to show for the ball and try to make something happen."
However, former Manchester United captain Roy Keane was not afraid to question the impact the ex-Ireland Under-21 international is capable of having.
"I am intrigued," Keane said. "You have said he has played 14 minutes of competitive football for England yet all of a sudden, I know Wrighty loves him and we all know he's got a chance of being a very good player.
"It's like he's the Messiah - the Messiah for England."
Although sceptics question Southgate's decision to continually pick Mason Mount ahead of Grealish, Keane stressed the midfielder will have to be patient to get his chance.
"But Jack will get his time," he added. "There are other games coming up.
"Gareth, from a manager's point of view, is thinking 'we are 1-0 down, still in the game and we just need one chance' and Jack will have to be patient."
Roy Keane cannot believe there are England fans who treat Jack Grealish as if he is the 'Messiah' of English football.