Carlo Ancelotti's side booked their spot in the last-16 stage of the Copa del Rey on Tuesday evening courtesy of a 1-0 success over Cacereno.
Los Blancos are currently second in the La Liga table, level on points (38) with leaders Barcelona.
Here, Sports Mole rounds up Real Madrid's latest injury and suspension news ahead of their contest with Villarreal, who currently occupy seventh in Spain's top flight.
Mariano Diaz
Status: Major doubt
Type of injury: Ankle
Possible return date: January 7 (vs. Villarreal)
Real Madrid were again without the services of Mariano Diaz for the clash with Cacereno, as the forward picked up an ankle injury during a recent training session, and he is also a major doubt for this game.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no players suspended for this clash.