Spurs, who occupy 10th position, are just two points clear of their opponents, who are currently propping up the WSL table.
Match preview
Having failed to pick up a point in the WSL since thrashing Brighton & Hove Albion 8-0 on October 30, Tottenham were aiming to end their poor run of form when they travelled to Prenton Park to face Liverpool on Sunday.
Spurs managed to open the scoring through Rosella Ayane, but goals from Emma Koivisto and Missy Bo Kearns gave the Reds a 2-1 half time lead.
With Tottenham unable to find an equaliser in the second period, they slumped to their ninth consecutive league defeat.
The result proved to be the final straw for the club's hierarchy, who made the decision to relieve Rehanne Skinner from her duties as Tottenham boss.
While Spurs begin the search for a new manager, Skinner's assistant Vicky Jepson will take charge of Wednesday's contest where Tottenham will attempt to end their winless run against a Leicester side that they beat 2-1 in September.
Although Leicester remain in the one and only relegation place, they will be satisfied with their recent form, with all seven of their WSL points arriving in their last five matches.
In their most recent outing, the Foxes held Everton to a goalless draw at the King Power Stadium, which represented the first time a Leicester league match has finished all square this season.
Willie Kirk will be pleased to see his side keep their third clean sheet in five WSL matches, but his team still have work to do in the final third.
The Foxes have failed to score in nine of their 14 league games this term and with only seven WSL goals to their name, they are currently the lowest scores in the top flight.
As they turn their focus to Wednesday's fixture, Leicester know that a point would move them above 11th-placed Brighton on goal difference, while a third league victory of the season would help them leapfrog their opponents.
Tottenham Hotspur Ladies Women's Super League form:
L
L
L
L
L
L
Tottenham Hotspur Ladies form (all competitions):
Leicester Women Women's Super League form:
L
W
L
W
L
D
Leicester Women form (all competitions):
Team News
The hosts are still unable to call upon the services of long-term injury absentees Kyah Simon, Ellie Brazil and Ria Percival.
Jess Naz will also miss out through injury, while Shelina Zadorsky is a doubt after missing the last two games through illness.
After coming off the bench at half time against Liverpool, Eveliina Summanen could be presented with a starting opportunity.
As for the visitors, Ava Baker is away on international duty with the England Under-17 side, while long-term absentees Abbie McManus, Jess Sigsworth and Lachante Paul remain sidelined.
Having missed Leicester's last two matches with an injury issue, Catherine Bott is a doubt for the midweek contest.
Kirk could freshen up his side with a couple of changes, which may result in Missy Goodwin and Carrie Jones being called into the starting lineup.
Tottenham Hotspur Ladies possible starting lineup:
Korpela; Turner, Bartrip, Harrop, Neville; James, Summanen; Bizet, Iwabuchi, Ayane; England
Leicester Women possible starting lineup:
Leitzig; Eaton-Collins, Howard, Plumptre, Nevin; Mace, Green; Whelan, Tierney, Cain; Goodwin