Meanwhile, the away side make the trip to Monterrey aiming to pick up back to back wins for the first time this term having returned to winning ways last time out.
Match preview
Tigres had to make do with a point for the second game running following a 1-1 draw against Juarez at the Estadio Olimpico Benito Juarez on Sunday.
Robert Siboldi's men went into the interval with the lead thanks to Luis Quinones' opener before Amaury Escoto restored parity in the 77th minute.
As a result, Los Auriazules have dropped down to 10th in the Liga MX table but are only one point adrift of the last automatic playoff spot.
Their next task sees them take on an opposing outfit against whom the last 12 meetings have ended in four wins apiece for either side and as many draws.
Currently without defeat in eight straight home matches, Sunday's hosts have established themselves as a dominant force to reckon with in front of their fans.
Club Leon put on a superb first-half performance to stroll to an emphatic 4-0 triumph over Pachuca in Tuesday's encounter at Estadio Leon.
Goals from Ivan Moreno, Jaine Barreiro and Jesus Angulo saw Nicolas Larcamon's men go into the break with a commanding lead before Brian Rubio put the final nail in the coffin with almost the last kick of the game.
Having now picked up three points from two matches, Los Panzas Verdes have moved up to sixth in the standings with the joint-best attacking record.
Off the back of ending a four-match winless streak away from home in their most recent outing, Sunday's visitors now seek consecutive wins on the road for the first time since March.
Tigres Liga MX form:
D
W
D
W
D
D
Club Leon Liga MX form:
L
D
W
L
L
W
Club Leon form (all competitions):
W
L
W
W
L
W
Team News
Andre-Pierre Gignac is yet to make an appearance for Tigres this term due to injury and he will not play any part in this weekend's match.
Raymundo Fulgencio was on target for the hosts in the last meeting between Sunday's opponents, making the midfielder one to keep an eye on here.
Jesus Angulo put on a man-of-the-match display for Club Leon against Pachuca and the 26-year-old will be looking to deliver the goods once again.
Fidel Ambriz made his return to action from a brief injury spell in the aforementioned game and the Mexican will be pushing for a place in the starting XI for this one.
Tigres possible starting lineup:
Guzman; Angulo, Pizarro, Reyes, Aquino; Vigon, Carioca, Gorriaran; Quinones, Ibanez, Fulgencio
Club Leon possible starting lineup:
Cota; Tesillo, Frias, Barreiro; Moreno, Angulo, Rodriguez, Hernandez; Mena, Alvarado, Davila