For Cambuur, securing back to back victories for the first time since the turn of the year will be the target as they aim to move out of the drop zone.
Match preview
PSV Eindhoven showed great mettle to see off the threat of a spirited RKC Waalwijk side in Sunday's 1-0 victory at the Mandemakers Stadion.
Ruud van Nistelrooy's men broke the deadlock 10 minutes shy of half time through Johan Bakayoko before resisting a second-half fightback to come away with all three points.
As a result, the Rood-witten remain fourth in the Eredivisie table, six points behind league leaders Feyenoord in what is set to be a frenetic title race this term.
Awaiting them next is the challenge of an opposing outfit who have come out on top in just one of the previous 17 meetings between the teams all the way back to 1992.
However, that solitary victory did come in the most recent clash back in October with Sunday's hosts falling to a comprehensive 3-0 defeat in this season's reverse fixture.
Cambuur picked up a first league victory in over five months courtesy of a 4-1 thrashing of Go Ahead Eagles at the Cambuur Stadion on Sunday.
Sjors Ultee's men edged in front through Michael Breij but were pegged back by Mats Deijl after which strikes from Mimoun Mahi, Bjorn Johnsen and Navarone Foor capped off a dominant display in style.
While the Yellow-Blues are still bottom of the league standings having picked up 16 points from their 24 outings, they have now moved within four points of safety.
With crucial relegation six-pointers against SBV Excelsior and FC Emmen to follow this weekend's contest, Sunday's visitors will be keen to stay within touching distance of their rivals in the fight for survival.
PSV Eindhoven Eredivisie form:
W
D
W
D
W
W
PSV Eindhoven form (all competitions):
L
D
W
W
W
W
Cambuur Eredivisie form:
L
L
D
L
L
W
Team News
First-choice goalkeeper Walter Benitez continues to nurse a knee injury, which will see Joel Drommel continue to feature between the sticks for PSV.
Guus Til and Thorgan Hazard also miss out through ankle and muscle injuries respectively, while Luuk de Jong is a major doubt after he came off with an injury doubt last time out.
Johan Bakayoko is one to look out for here having been directly involved in five goals in as many matches since his return to the starting XI.
NEC's Maxim Gullit is yet to make an appearance this term due to a long-term injury and the 21-year-old still faces an extended period out of action.
Silvester van der Water starred for the away side in October's reverse fixture but the Dutchman heads into this weekend's game having failed to score since then.
PSV Eindhoven possible starting lineup:
Drommel; Van Aanholt, Branthwaite, Ramalho, Mwene; Sangare, Veerman, Simons; Bakayoko, Silva, El Ghazi
Cambuur possible starting lineup:
Ruiter; Schmidt, Bergsma, Smand, Van Wermeskerken; Van Kaam, Paulissen, Foor; Breij, Johnsen, Mahi