Both sides are looking for their first win of the Women's Euro 2022 after the Netherlands drew 1-1 with Sweden in their opener, while Portugal fought back from two goals down to draw 2-2 against Switzerland.
Match preview
The reigning European champions clinched a point from their opening match against a Sweden side that are ranked by FIFA as the second-best team in the world.
Jonna Andersson struck in the first half to give Sweden the lead, but Jill Roord found the net after the interval, ensuring her side avoided defeat in their tournament opener.
They will now turn their attention to matchday two where they will be aiming to collect their first win of the tournament against Portugal.
After winning four of their previous six matches, the Netherlands will be confident of claiming three points on Wednesday.
They will also be looking to continue their impressive goalscoring run after finding the net in 19 of their previous 20 internationals.
Meanwhile, Portugal demonstrated great fight to come back from two-goals down to collect a point against Switzerland in their opening game.
Francisco Neto's side got off to a disastrous start, conceding two goals inside the opening five minutes to leave themselves with a mountain to climb.
However, they fought back after the break, with Diana Gomes halving the deficit before Jessica Silva restored parity in the 65th minute.
Portugal pressed on in search of a winner but ultimately had to settle for what could prove to be a valuable point in their quest to reach the knockout rounds.
As a result of the draw, Portugal will take a five-game unbeaten run into Wednesday's contest where they will be looking to clinch their first win of the tournament.
Netherlands Women Women's European Championship form:
Netherlands Women form (all competitions):
Portugal Women Women's European Championship form:
Portugal Women form (all competitions):
Team News
Netherlands goalkeeper Sari van Veenendaal has been ruled out for the rest of the tournament due to a shoulder injury, which forced her off after 21 minutes against Sweden.
Daphne van Domselaar will replace Van Veenendaal, while Mark Parsons could also be forced into a change in defence after Aniek Nouwen had to be withdrawn in the first half of Saturday's encounter due to an injury issue.
Nouwen's absence could result in a starting place for Marisa Olislagers, who is expected to partner Stephanie van der Gragt in the Netherlands defence.
As for Portugal, they could name an unchanged lineup for Wednesday's contest after fighting back from two goals down to draw against Switzerland.
Gomes found the net on Saturday, but her main priority on matchday two will be keeping the Netherlands attack at bay when she partners Carole Costa in the centre of defence.
Meanwhile, Jessica Silva will continue to operate in a front three alongside Ana Borges and Diana Silva.
Netherlands Women possible starting lineup:
Van Domselaar; Wilms, Van der Gragt, Olislagers, Janssen; Groenen, Van de Donk, Spitse; Roord, Martens, Miedema
Portugal Women possible starting lineup:
Pereira; Amado, Gomes, Costa, Marchao; Ferreira, D. Silva, Norton; Borges, D. Silva, J. Silva