Both sides are on an impressive run of results heading into their last-eight meeting and the game promises to be a keenly-contested affair.
Match preview
NEC Nijmegen saw off the threat of Go Ahead Eagles in the sides' KNVB Beker round-of-16 encounter which ended in a 2-1 victory on January 17.
Rogier Meijer's men opened the scoring 10 minutes from half time through Koki Ogawa and doubled their advantage thanks to Sai Van Wermeskerken before Robin Roefs turned the ball past his own goalkeeper to set up a frenetic finish.
The Eniesee have picked up seven points from their subsequent three league matches and moved up into seventh in the Eredivisie table as a result.
Coming up next is the challenge of an opposing outfit with little to choose between the teams over the last 10 clashes which have yielded four wins apiece and two draws.
Having come out on top in each of their last five matches on home turf, Tuesday's hosts will back themselves to keep the juggernaut rolling in front of their fans.
ADO Den Haag put on a late show to narrowly edge out Excelsior Maassluis and make it through to the last eight of this year's Dutch Cup.
Darije Kalezic's men went behind to Kevin Dercks's early strike after which Jort van der Sande and Henk Veerman netted late on to complete a remarkable turnaround.
De Ooievaars claimed a 3-1 win over Oss in their most recent league outing and currently sit second in the Eerste Divisie, five points behind leaders Willem II.
Unbeaten in 13 of their last 15 matches on the road, Tuesday's visitors have proven themselves to be a tough nut to crack away from home.
NEC KNVB Beker form:
W
W
NEC form (all competitions):
W
D
W
W
D
W
ADO Den Haag KNVB Beker form:
W
W
ADO Den Haag form (all competitions):
W
W
W
L
W
W
Team News
Bas Dost remains out of contention for NEC Nijmegen due to a heart problem, while Lasse Schone continues to recuperate from a muscle injury.
Dutch trio Youri Baas, Nils Rossen and Kas de Wit also miss out for the home side and are joined on the sidelines by Brayann Pereira.
Henk Veerman has found the back of the net in four of his last five outings for Den Haag, making the forward one to keep an eye on here.
Twenty-one-year-old Hugo Wentges is still battling with a long-term knee problem which has seen him fail to feature for the away side since September.
NEC possible starting lineup:
Cillessen; Van Rooy, Sandler, Nuytinck, Verdonk; Proper, Hoedemakers; Hansen, Chery, Sano; Ogawa
ADO Den Haag possible starting lineup:
Marsman; Van Hintum, Waem, Asante, Che; Vigen, Suermeli; Ideho, Van der Sande, Van Mieghem; Veerman