Both sides came away with maximum points from their respective last outings and will be looking to pick up where they left off last time out.
Match preview
Crawley Town snapped a run of two defeats on the bounce with a 2-0 triumph over Gillingham in Tuesday's clash at the Priestfield Stadium.
Scott Lindsey's men got their noses in front courtesy of Will Wright's opener after which Jack Roles put the result beyond doubt in the 70th minute.
Consequently, the Red Devils have moved up to 11th in the League Two table and are now just three points adrift of the final playoff place.
Lying in store next is the challenge of an opposing outfit who have only been beaten in one of the last five editions of this fixture.
However, that solitary defeat did come in the most recent meeting back in August when Friday's visitors claimed a 2-1 win in this season's earlier encounter.
MK Dons made it three wins on the spin following a narrow 1-0 victory over Colchester United when the teams locked horns on Tuesday afternoon.
Mike Williamson's men were in the ascendancy for large spells of the game but needed an 89th-minute winner from Ellis Harrison to get the job done.
With 36 points picked up from 22 matches so far, The Dons sit seventh in the standings and are hanging on to the final promotion playoff berth by just one point.
Unbeaten in all but one of their last eight matches on home turf, Friday's hosts have established themselves as a force to reckon with in front of their fans.
MK Dons League Two form:
D
W
D
W
W
W
MK Dons form (all competitions):
W
D
L
W
W
W
Crawley Town League Two form:
W
L
W
L
L
W
Crawley Town form (all competitions):
L
W
W
L
L
W
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Team News
Ellis Harrison came off the bench to good effect for MK Dons last time out and could be rewarded with a place in the starting lineup here.
After managing just four goals in his opening 11 games of the season, Max Dean has scored four times in his last five matches for the home side and is one to look out for.
Twenty-three-year-old Jay Williams is eligible to feature for Crawley Town once again having fully served his suspension against Gillingham.
Defender Will Wright has chipped in with goals in each of his last two outings for the away side and will be looking to deliver the goods once again.
MK Dons possible starting lineup:
MacGillivray; Williams, O'Hora, Lewington; Norman, Payne, Robson, Tomlinson; Gibey, Dean, Leko
Crawley Town possible starting lineup:
Addai; Maguire, Conroy, Ransom; Gordon, Wright, Lolos, Tsaroulla; Darcy, Campbell, Orsi-Dadomo