The Reds, meanwhile, have the chance to complete a league double after beating Tottenham Hotspur 2-1 in their most recent outing.
Match preview
Everton were not in action at the weekend due to the FA Cup quarter-finals, which gave them plenty of time to ponder over their goalless draw against basement side Leicester City.
The result would have frustrated Everton boss Brian Sorensen with his side now winless in four games across all competitions.
Although wins have proven to be hard to come by in recent weeks, Sorensen will be pleased with the progress his side have made in his first season in charge, having already matched their 20-point tally from the 2021-22 campaign.
As a result, sixth-placed Everton are currently six points better off than their local rivals, who they comfortably swept aside when the two sides met earlier this season.
Goals from Megan Finnigan, Jess Park and Hanna Bennison guided the Toffees to a 3-0 victory at Anfield, ensuring Everton have now won their last three competitive meetings with Liverpool.
Liverpool bounced back from consecutive defeats against Leicester and Arsenal to beat Tottenham 2-1 in their previous fixture on March 12.
Rosella Ayane gave Spurs the lead, but goals from Emma Koivisto and Missy Bo Kearns ensured the Reds took a narrow advantage into half time, with Tottenham unable to find an equaliser in the second period, Liverpool held firm to claim a narrow win.
As a result of their third WSL victory of the season, Liverpool have moved seven points clear of the one and only relegation place.
Although the Reds look well set to avoid an immediate return to the Championship, they have struggled on their travels this season, picking up two points from their six away league matches.
As one of two teams yet to win a league game on the road this season, Liverpool will be desperate to secure a victory in one of their final four away fixtures of the 2022-23 campaign.
Everton Ladies Women's Super League form:
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Everton Ladies form (all competitions):
Liverpool Women Women's Super League form:
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Liverpool Women form (all competitions):
Team News
Everton could be without the services of goalkeeper Emily Ramsey, who has been sidelined in recent weeks with an ankle problem.
Sara Holmgaard has missed Everton's last three games due to an injury, and she is expected to be unavailable for Friday's derby.
Aggie Beever-Jones could be brought into the side to feature in a front three alongside Jess Park and Katja Snoeijs.
As for the Reds, they are unable to call upon Leanne Kiernan, Shanice van der Sanden, Natasha Dowie and Niamh Fahey due to injury issues.
Jasmine Mathews and Megan Campbell have been absent from the last two games due to hip problems, and they remain doubts for Friday's contest.
Katie Stengel has scored six goals in 14 league games this season, and she will be looking to add to her tally when she leads the line.
Everton Ladies possible starting lineup:
Brosnan; Finnigan, K. Holmgaard, Sevecke; Hope, Wheeler, Bjorn, George; Beever-Jones, Park, Snoeijs
Liverpool Women possible starting lineup:
Laws; Koivisto, Robe, Bonner, Campbell, Hinds; Kearns, Nagano, Holland, Daniels; Stengel