The Three Lions defeated reigning champions Italy 2-1 in Naples on Thursday, while the visitors are kickstarting their bid for tickets to Germany this weekend.
Match preview
Less than two months after becoming the greatest goalscorer in the history of Tottenham Hotspur, Harry Kane now stands alone at the top of the England goalscoring charts with 54 goals, leaving Wayne Rooney behind with what turned out to be the winning goal against Italy in midweek.
Following Declan Rice's 13th-minute opener, Kane banished his penalty demons from the World Cup to double England's lead before the break, but a resurgent Azzurri threatened a late comeback through debutant Mateo Retegui - Luke Shaw's late sending off hardly helped matters for the visitors either.
However, Gareth Southgate's side travelled home from Naples with a first win over Italy away from home in 61 years - earning a slice of revenge for their Euro 2020 final loss to Roberto Mancini's men - and the Three Lions have already assumed their role as table-toppers in Group C.
Ahead of North Macedonia on away goals scored after one game, England take to the field at Wembley aiming to record an 11th European Championship qualifying home win on the bounce, having prevailed in 10 such fixtures since drawing 2-2 with Switzerland in 2011.
Since that four-goal stalemate, the Three Lions have struck 38 goals and conceded just four at home in Euro qualifying - scoring at least twice in each of their last nine - and Ukraine will need more than just fresh legs to put Southgate's side to the sword here.
En route to the final two years ago, England sent Ukraine packing with a 4-0 thrashing in the quarter-finals, and the visitors' efforts to redeem themselves with qualification for the 2022 World Cup ultimately failed to bear fruit.
Amid the untold devastation in their homeland, Ukraine took a giant step towards flights to Qatar with a 3-1 win over Scotland in their playoff semi-final, but a Gareth Bale-inspired Wales ended Ukraine's World Cup dreams with a 1-0 win at the final hurdle.
Prior to stepping down from his position in January, manager Oleksandr Petrakov oversaw an indifferent UEFA Nations League campaign, as Ukraine won three, drew two and lost one of their League B Group 1 contests with Armenia, Scotland and the Republic of Ireland to finish second behind Steve Clarke's men - failing to earn an immediate promotion back to League A in the process.
Now under the temporary tutelage of 41-year-old caretaker boss Ruslan Rotan - a former 100-cap international - Ukraine begin their quest to qualify for the Euros for the fourth time in a row, but pipping 2020 finalists England and Italy to one of the top two spots in Group C will be a tall order.
Nevertheless, Rutan's side bring a 10-game unbeaten run in Euros qualifying to the English capital - having not suffered defeat away from home in such games since a 1-0 loss to Spain on March 27, 2015 - coincidentally the same day that Kane struck the first of his 54 goals in a Three Lions jersey.
England Euro Champ Qualifying form:
W
England form (all competitions):
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D
W
W
L
W
Ukraine form (all competitions):
W
W
D
L
W
D
Team News
Only a minute after being booked for taking too long on a throw-in, Shaw received his marching orders for a challenge on Retegui, so Ben Chilwell should cover for the suspended Manchester United man here.
A worrying sight for Borussia Dortmund fans, Jude Bellingham limped off the field late on and will need assessing ahead of this contest, but Jordan Henderson and Conor Gallagher are both on standby if the in-demand teenager does not make the cut.
Given the quick turnaround from their flight home, Southgate may ponder a few more alterations, with the likes of Reece James and Phil Foden - who played just 12 minutes as a substitute against Italy - under consideration for starts.
Meanwhile, Ukraine - like many other nations this month - have already been dealt a couple of injury blows, with Bournemouth centre-back Ilya Zabarnyi absent alongside 24-cap midfielder Oleksandr Zubkov.
Oleksandr Zinchenko has not had the best of luck with injuries at Arsenal this season, but the 26-year-old is already adored at the Emirates Stadium and should revert to his recognisable midfield role for the national team here.
Chelsea's Mykhaylo Mudryk should also be handed a start on the Wembley soil despite his slow start to life in England, while Andriy Yarmolenko - who is now on the books with Al Ain in the United Arab Emirates - needs three more goals to draw level with Andriy Shevchenko's 48 at the top of the Ukrainian charts.
The former West Ham United man has been absent for the whole of March due to a hamstring injury, though, so Girona winger Viktor Tsygankov may be preferred from the off.
England possible starting lineup:
Pickford; James, Stones, Maguire, Chilwell; Henderson, Phillips, Rice; Saka, Kane, Foden
Ukraine possible starting lineup:
Lunin; Konoplya, Matvienko, Popov, Mykolenko; Malinovskyi, Stepanenko, Zinchenko; Tsygankov, Dovbyk, Mudryk
We say: England 2-0 Ukraine
Despite possessing non-jellied legs and a possible new manager bounce, Ukraine's unbeaten streak in Euros qualifying should come to a swift end at the Wembley fortress.
While the scoreline may not be as emphatic as it was during their Euro 2020 quarter-final, Southgate's squad could and probably should have scored more in the first half against Italy, and a routine home win should be on the cards no matter how many changes the England boss considers.