A last-gasp own goal saw the Brazilian outfit escape from the home leg with an advantage, but that will be put to the test when they go on their travels to finish the job.
Match preview
Club Libertad Copa Sudamericana form:
Club Libertad form (all competitions):
Santos Copa Sudamericana form:
Santos form (all competitions):
Team News
Given their need for goals, Club Libertad may call upon experienced forward Oscar Cardozo, who has 54 Paraguay caps and 12 international goals to his name, while also having hit 58 goals in 136 appearances for the club after previously netting 112 games in a successful spell at Benfica.
Daniel Bocanegra also brings experience in the middle, while Ramon Martinez could be the midfielder sacrificed to allow for another attacking spot.
Santos come into the game without centre-back Kaiky Fernandes, who will serve a suspension after he was shown a red card in the first leg.
In his absence, Wagner Leonardo should come in to partner Luiz Felipe at the heart of the back four.
The threatening trio of Carlos Sanchez, Gabriel Pirani and Lucas Braga should again feature, likely supporting Marcos Guilherme as a lone striker.
Club Libertad possible starting lineup:
Silva; Mayada, Viera, Barboza, Vangioni; Villalba, Bocanegra, Martinez, Melgarejo; Cardozo, Ferreira
Santos possible starting lineup:
Paulo; Madson, Filipe, Leonardo, Jonatan; Camacho, Mota; Sanchez, Pirani, Braga; Guilherme
We say: Club Libertad 1-1 Santos (Santos win 3-2 on aggregate)
Santos certainly face a tough test as they arrive in Paraguay with a slender lead to defend, but we see them narrowly escaping with an aggregate win.
Libertad will put the Brazilian outfit on the back foot, and will have their chances to win the game, but we would not look past Santos getting a goal of their own to stay in front.