The away side, on the other hand, remain in contention for a European place and make the journey to Leeuwarden knowing that nothing but three points would suffice.
Match preview
Waalwijk suffered a fourth defeat in five matches as they were comprehensively beaten by FC Twente 5-0 at the Mandemakers Stadion on Sunday afternoon.
Joseph Oosting's men fell behind to first-half strikes from Gijs Smal and Manfred Ugalde, before Ramiz Zerrouki, Michal Sadilek and Julio Pleguezuelo netted in the second period to seal the deal.
As a result, RKC remain ninth in the Eredivisie table, two points behind Heerenveen in the race for the final Conference League playoff spot heading into the final weekend.
Next up is the task of facing off against an opposing outfit with only one defeat in the last 13 editions of this fixture across all competitions dating back to 2013.
However, that solitary loss did come in the most recent encounter back in September when Sunday's visitors claimed a thrilling 5-1 win in this season's reverse meeting.
Cambuur came away empty-handed from the ninth game on the bounce following a 4-1 defeat against Sparta Rotterdam at the Sparta Stadion Het Kasteel on Sunday.
Sjors Ultee's men took a shock lead in the ninth minute through Marco Tol after which goals from Koki Saito, Michael Pinto, Joshua Kitolano and Younes Namli turned the game on its head.
With 16 points picked up from their 33 matches this term, The Yellow-Blues remain rooted to the bottom of the standings and are set to finish the season there.
Having picked up the fewest points on home turf this term, Sunday's hosts will be keen to put on a show for their fans as they prepare to return to the second tier of Dutch football.
Cambuur Eredivisie form:
L
L
L
L
L
L
RKC Waalwijk Eredivisie form:
W
L
L
W
L
L
Team News
Maxim Gullit remains out of contention for Cambuur due to a knee injury as the 21-year-old still awaits his first appearance of the current campaign.
The hosts are also missing the services of Robin Maulun and Vincent Pichel, while Mimoun Mahi is set to miss a second consecutive game due to a torn muscle.
Waalwijk's Mats Seuntjens made his return to action from a brief injury spell last time out and he is expected to reclaim his place in the starting lineup.
The Dutchman, who has been directly involved in four of his side's last six goals away from home, will need to be on song if the visitors are to come away with a positive result.
Cambuur possible starting lineup:
Minnema; Sylla, Bergsma, Tol, Wermeskerken; Rienstra, Van Kaam; Balk, Foor, Breij; Uldrikis
RKC Waalwijk possible starting lineup:
Vaessen; Lelieveld, Gaari, Adewoye, Lutonda; Oukili, Anita; Seuntjens, Clement, Bakkali; Kramer