Barcelona are currently top of their Women's Champions League group after picking up maximum points from their three matches, while Bayern are three points adrift in second place.
Match preview
Bayern Munich had to come from behind to beat Rosengard and Benfica in their opening two group games, but they were unable to trouble the 2020-21 European champions on matchday three.
The German club were swept aside by a 3-0 scoreline that leaves them in second place and just three points better off than Benfica, who currently sit in third position.
Since losing to Barcelona, Alexander Straus's side have recorded two straight victories in the league, including a comfortable 4-0 win over Hoffenheim on Friday.
Maximiliane Rall and Linda Dallman grabbed a goal apiece to give Bayern a two-goal lead, before Lea Schuller netted a brace to wrap up a commanding victory.
While Bayern will face a tougher test on Wednesday, they can draw inspiration from the fact that they have won all six of their competitive home games this season.
Meanwhile, Barcelona are looking to maintain their 100% record in all competitions after winning 14 consecutive games this season.
Three of those victories have taken place in the Champions League, where they began their European campaign with a memorable 9-0 win over Benfica.
Rosengard were then brushed aside by a 4-1 scoreline, before goals from Geyse, Aitana Bonmati and Claudia Pina guided Barcelona to a comfortable 3-0 home victory against Bayern two weeks ago.
In their most recent outing, Barcelona had to come from behind to beat Real Sociedad thanks to a Marta Torrejon equaliser and Lucy Bronze's 89th-minute winner.
After racking up 28 goals across their seven competitive away games this season, Barcelona will be looking to continue their impressive form on Wednesday.
Bayern Munich Women Women's Champions League form:
Bayern Munich Women form (all competitions):
Barcelona Women Women's Champions League form:
W
W
W
Barcelona Women form (all competitions):
Bayern Munich are unable to call upon the services of Jovana Damnjanovic, Hanna Glas and Giulia Gwinn due to injury issues.
Tainara is expected to continue her centre-back partnership with Glodis Viggosdottir, and the pair will have the tricky task of keeping Barcelona's forward line at bay.
Schuller came off the bench to score a brace against Hoffenheim, and she will be brought into the starting lineup for Wednesday's contest.
As for the visitors, they are expected to make a number of changes after rotating their side for Saturday's league game against Real Sociedad.
Fridolina Rolfo and Bronze will come into the back four to operate as the two full-backs, while Irene Paredes is expected to return to the side to partner Mapi Leon in central defence.
Giraldez will also bring Mariona Caldentey and Geyse into the starting lineup to feature in the front three alongside Pina.
Bayern Munich Women possible starting lineup:
Grohs; Rall, Tainara, Viggosdottir, Simon; Magull, Stanway, Zadrazil; Lohmann, Buhl, Schuller
Barcelona Women possible starting lineup:
Panos; Bronze, Paredes, Mapi Leon, Rolfo; Bonmati, Walsh, Guijarro; Crnogorcevic, Pina, Geyse
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