The Premier League club started off their UCL campaign with a thrilling 6-3 win over RB Leipzig, while PSG were held to a 1-1 draw by Club Brugge.
City will be hoping for a tighter defence this time out as they head to Paris to face the French side who have added some big names to their squad.
The Ligue 1 giants will be out for revenge after their semi-final exit against the Premier League champions last season.
City lost to Chelsea in the final though and will be desperate to go one better this season as Pep Guardiola looks to finally claim European glory.
PSG v Man City: talkSPORT commentary
The Champions League Group A clash will take place on Tuesday, September 28 and will kick-off at 8pm.
Your presenter for the evening is Adrian Durham while commentary will come from Sam Matterface and former Manchester City and England defender Danny Mills.
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PSG v Man City: Team news
Ilkay Gundogan will miss City's trip to Paris.
The German midfielder has been out since suffering a knock against Southampton earlier this month and has now been ruled out until after the October international break.
Left-back Oleksandr Zinchenko is City's only other notable absentee with a calf problem.
Lionel Messi is a doubt after picking up a knock against Lyon earlier this month, but could return against the Premier League champions.
Sergio Ramos is also doubtful as the summer signing has been suffering with a calf injury since late July.
PSG v Man City: What's been said?
Man City boss Pep Guardiola: "What happened last season was last season. They were a fantastic team and it was a tight game and now they have Messi.
"With this quality I don't know what we can do, honestly!
"They are fantastic team. What could I say with the players they have: Marquinhos, I'm a big fan of him. Hakimi, Paredes, Verratti, especially, and the players upfront - they can play wide, narrow, middle. They combine really well and have quality.
"Talent cannot be stopped. We don't put pressure on one player to stop the talent they have - we do it as a team. We know we will suffer - this level demands this. They are so good and you have to be able to suffer for 90 minutes.
"To control is so difficult. We will try to defend well when we don't have the ball and let them run when we have it.
"They are exceptional players - everyone knows it. All of them are so good. They can combine and connect. We are looking forward to the game and we will play."