Having suffered an early exit from this year's edition of football's biggest event, Felix Sanchez's men will be looking to bow out in style.
Louis van Gaal's men, on the other hand, set out to confirm their place in the knockout phase and possible finish as winners of Group A.
Here, Sports Mole looks at how the squads of Netherlands and Qatar stack up against each other ahead of Tuesday's matchup.
NETHERLANDS
Most valuable player:
Matthijs de Ligt (£60.8m)
Overall squad value:
£510.1m
Most capped player:
Daley Blind (96)
Leading goalscorer:
Memphis Depay (42)
Total caps:
713
Total goals:
108
Oldest player:
Remko Pasveer (39)
Youngest player:
Xavi Simons (19)
Average age:
26.6
SQUAD IN FULL
Goalkeepers: Justin Bijlow (Feyenoord), Andries Noppert (Heerenveen), Remko Pasveer (Ajax)
Defenders: Virgil van Dijk (Liverpool), Nathan Ake (Manchester City), Daley Blind (Ajax), Jurrien Timber (Ajax), Denzel Dumfries (Inter Milan), Stefan de Vrij (Inter Milan), Matthijs de Ligt (Bayern Munich), Tyrell Malacia (Manchester United), Jeremie Frimpong (Bayer Leverkusen)
Midfielders: Frenkie de Jong (Barcelona), Steven Berghuis (Ajax), Davy Klaassen (Ajax), Teun Koopmeiners (Atalanta BC), Marten de Roon (Atalanta BC), Kenneth Taylor (Ajax), Xavi Simons (PSV Eindhoven)
Forwards: Cody Gakpo (PSV Eindhoven), Memphis Depay (Barcelona), Steven Bergwijn (Ajax), Vincent Janssen (Antwerp), Luuk de Jong (PSV Eindhoven), Noa Lang (Club Brugge), Wout Weghorst (Besiktas)
QATAR
Most valuable player:
Akram Afif (£3.5m)
Overall squad value:
£13m
Most capped player:
Hassan Al-Haydos (171)
Leading goalscorer:
Almoez Ali (42)
Total caps:
1,500
Total goals:
193
Oldest player:
Abdulaziz Hatem (32)
Youngest player:
Jassem Jaber (20)
Average age:
26.9
SQUAD IN FULL
Goalkeepers: Saad Al Sheeb (Al Sadd), Mishaal Barshim (Al Sadd), Youssef Hassan (Al-Gharafa)
Defenders: Ro-Ro (Al-Sadd), Abdul Karim Hassan (Al-Sadd), Tariq Salman (Al-Sadd), Musab Khader (Al-Sadd), Homam Ahmed (Al-Gharafa), Bassam Al-Rawi (Al-Duhail), Boualem Khoukhi (Al-Sadd), Jassem Jaber (Al-Arabi), Ismaeel Muhammad (Al-Duhail)
Midfielders: Abdulaziz Hatem (Al-Rayyan), Muhammad Waad (Al Sadd), Ali Assadalla (Al Sadd), Salem Al Hajri (Al Sadd), Karim Boudiaf (Al-Duhail), Assim Madibo (Al-Duhail), Mustafa Tarek (Al Sadd)
Forwards: Akram Afif (Al Sadd), Ahmed Alaaeldin (Al-Gharafa), Mohammed Muntari (Al-Duhail), Hassan Al-Haydos (Al Sadd), Khalid Muneer (Al-Wakra), Almoez Ali (Al-Duhail), Naif Al-Hadhrami (Al-Rayyan)
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