According to The Sun, the Man United star was out with his friends when he saw the Aston Villa Women's midfielder entering the venue.
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Lehmann and her friends were soon surrounded by a group men, leading Rashford to step in.
The England international is said to have invited Lehmann and her friends into his VIP section so that they could enjoy their night in peace.
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A source from Chinawhite in Manchester told The Sun: "Marcus cleared a table and invited her and her friends to join them.
"It was the first time they'd met but he knew who Alisha was.
"They exchanged a few words and she thanked him then they carried on partying with their separate sets of friends.
"She thought he was a gent."
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Lehmann is one of the of women's football's most famous stars.
As well as being a key player for Aston Villa Women, the 24-year-old also boasts 13million followers on Instagram.