Pep Guardiola is yet to achieve continental glory with the reigning Premier League champions, who were dramatically dumped out by Real Madrid 6-5 on aggregate in last year's semi-finals.
The Citizens also dropped another two points in the English top flight at the weekend, with Aston Villa managing to glean a point in a 1-1 draw.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the meeting with Los Palanganas.
Aymeric Laporte
Status: Out
Type of injury: Knee
Possible return date: Unknown
Centre-back Aymeric Laporte remains the Citizens' only long-term absentee as he recovers from knee surgery, and the Spaniard is unlikely to be back in training before the international break.
Kalvin Phillips
Status: Minor doubt
Type of injury: Shoulder
Possible return date: September 6 (vs. Sevilla)
Kalvin Phillips's shoulder problem did not let up in time for him to take part at Villa Park, but the former Leeds United man could recover in time to travel to Spain.
Kyle Walker
Status: Major doubt
Type of injury: Unspecified
Possible return date: September 6 (vs. Sevilla)
Right-back Kyle Walker was forced off with an unspecified injury with 10 minutes to go against Villa at the weekend. Guardiola was unable to comment on the severity of the 32-year-old's problem, so it remains to be seen if he can play on Tuesday.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no suspended players for this game.