Cristiano Ronaldo was the star of the show with his brace proving decisive against Mikel Arteta's impressive side.
The Red Devils go into the match on the back of a 1-1 draw with Chelsea last
The Gunners took the lead in controversial fashion as Emile Smith Rowe found the net with David De Gea on the floor with an injury, however the goal was given.
Bruno Fernandes levelled, before Ronaldo struck from close range to put United in front.
That lead didn't last long, however, with Martin Odegaard striking low to make it 2-2.
However Ronaldo struck again from the penalty spot to give Michael Carrick the perfect send-off as caretaker boss.
Full-time: Manchester United 3-2 Arsenal
Cristiano Ronaldo brace secures win after controversial Emile Smith Rowe opener
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