The 31-year-old's 12th treble came in Man City's 6-1 win over Aston Villa on Sunday.
Now, he has overtaken Newcastle legend Alan Shearer in Premier League hat-tricks in what was a record-breaking day.
Aguero also surpassed Thierry Henry's top-flight goal record to become the highest scoring overseas player in the Premier League.
Most hat-tricks scored in Premier League history
Sergio Aguero – 12
Alan Shearer – 11
Robbie Fowler – 9
Harry Kane, Thierry Henry, Michael Owen – 8
Wayne Rooney – 7
Luis Suarez – 6
Dimitar Berbatov, Andy Cole, Ruud van Nistelrooy, Robin van Persie, Ian Wright – 5
The former Arsenal striker netted 175 goals in a nine-year spell in north London.
Aguero's stats are incredible - he has now scored 177 league goals in 255 appearances since joining Man City in 2011.
LATEST FOOTBALL NEWS
Legend
Sergio Aguero will die scoring goals, jokes jubilant Pep Guardiola
latest
Man United news live: Pogba could go to Inter in swap deal, Fernandes latest
LATEST
Arsenal news live: Upamecano move hijacked, Gunners urged to sign Ndidi
contrast
Drinkwater vs Mahrez - Leicester's heroes whose careers have taken different turns
Wanted
Tottenham targeting out-of-favour Inter Milan striker
Ruthless
Man City thump Aston Villa as Aguero surpasses Henry goal record
PURE CLASS
Aguero beats stunning Premier League record set by Arsenal legend Henry
REVEALED
What Chelsea will reportedly have to pay to land Lewis Dunk in January
HERO
Xavi gives up his 'dream' to become Barcelona manager for incredible reason
Close
Asmir Begovic undergoing medical at AC Milan ahead of loan move
Harry Kane is the closest current player on eight top-flight hat-tricks to catching Aguero.
It was a ruthless performance from Pep Guardiola's side, who were 4-0 up at half-time thanks to Riyad Mahrez (2), Aguero and Gabriel Jesus strikes.
The Argentina forward added two more goals in the second-half to further humiliate Villa in their own backyard.
Sergio Aguero has scored the most hat-tricks in Premier League history.
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Atletico Madrid 
Alaves 
Rangers 
Dundee Utd 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Bordeaux 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen 
Celta Vigo 
Barcelona 
Benfica 
Estrela Da Amadora 
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano