The Reds secured a 2-0 first-leg lead in Italy last month thanks to goals from Roberto Firmino and Mohamed Salah.
Jurgen Klopp's side are always formidable at Anfield in European games and Inter face a huge task to turn the tie around.
The Nerazzurri are second in the Serie A table at the moment and smashed Salernitana 5-0 last time out.
But, as Liverpool chase an unprecedented quadruple this season, the Reds will be confident of securing their passage into the next round.
Liverpool v Inter Milan: Date and time
The Champions League last-16 second leg tie will take place on Tuesday, March 8 at Anfield.
Kick-off is scheduled for 8pm.
The draw for the Champions League quarter-finals will be held on March 18.
Liverpool v Inter Milan: How to follow
The contest at Anfield will be broadcast live on BT Sport 2.
Coverage will get underway at 7pm, with BT Sport customers able to live stream this via the app using their mobile, tablet or computer devices.
Liverpool v Inter Milan: Team news
Liverpool trio Thiago Alcantara, Joel Matip and Roberto Firmino have all returned to training ahead of the visit of Inter Milan.
Alcantara and Matip will be in the squad after a thigh injury and illness respectively.
A late decision will be taken on Firmino, who has not played since the first meeting with the Italians in mid-February because of a groin injury.
Liverpool provisional squad: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Henderson, Thiago, Salah, Jota, Mane, Kelleher, Adrian, Gomez, Konate, Tsimikas, Keita, Milner, Oxlade-Chamberlain, Elliott, Jones, Diaz, Minamino, Origi, Firmino
Liverpool v Inter Milan: What's been said?
Inter Milan defender Alessandro Bastoni: "They have some top players who are up there among the best in Europe.
"If you are scared to play in these games it is not the right job for you. I can't wait for the game.
"I've been against top players like Cristiano Ronaldo, Karim Benzema and Vinicius Jnr, who are all top European players as well.
"Salah, (Sadio) Mane and (Diogo) Jota are all fantastic players but we will need to play very well tomorrow and show our team spirit - that goes for me and all the other players.
"It is the first time for many of us playing at this level in Europe (Inter are in the last 16 for the first time in a decade) so it is an opportunity to improve and gain more confidence.
"It will be a wonderful experience. I've been dreaming of playing in English stadiums and got to do so at Wembley in the summer and that one went our way."