The Foxes have played just once since the turn of the year, a match that saw them secure a 4-1 victory over Watford in the FA Cup.
For Spurs this is a match they simply need to win.
After crashing out of the Carabao Cup semi-finals against Chelsea, Antonio Conte's side will be determined to continue their improved form in the league as they look to challenge for a top four finish.
Leicester v Tottenham: Date and time
The Premier League clash is set to take place on Wednesday, January 19 at the King Power Stadium in Leicester.
Kick-off is scheduled for 7.30pm UK time.
Victory could see Spurs move up to fifth spot in the table.
Leicester v Tottenham: talkSPORT coverage
Coverage will get underway at 7.15pm, with commentary coming from Joe Shennan and Sheffield United Women's striker Courtney Sweetman-Kirk.
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Leicester v Tottenham: Team news
Brendan Rodgers faces something of a selection crisis with plenty of players set to miss out.
Kiernan Dewsbury-Hall, Luke Thomas, Çağlar Söyüncü, Patson Daka and James Justin are in contention.
Boubakary Soumaré and Ayoze Pérez could return.
Wesley Fofana, Jonny Evans, Ricardo Pereira, Ryan Bertrand and Jamie Vardy are certain to miss out through injury, while Timothy Castagne is out after undergoing an operation.
Meanwhile, Wilfred Ndidi, Daniel Amartey, Nampalys Mendy and Kelechi Iheanacho will also miss out due to being away on AFCON duty.
Spurs will also have to cobble a team together with several injury problems of their own.
Heung-min Son will miss out, while Eric Dier, Cristian Romero and Sergio Reguilon will be hoping to be passed fit for the contest.
Leicester v Tottenham: What has been said?
Leicester boss Brendan Rodgers: "Antonio [Conte's] come in and given them a stable base, they're playing a similar style as they were under Nuno [Espírito Santo].
"The players know the system and where they're playing. They're a very good team with very good players."
Tottenham boss Antonio Conte: "We know that we have to play against a really good team that in the last years they won a title, they are showing they are doing important things in England.
"I think that we have to continue to try to have a good result in the league.
"We know that only after the international break the injured players are ready to come back and it will be difficult to come back from this period.
"It's not easy to come back from this period when you have many injuries in your squad.
"Then we'll see if anything comes from this period in the transfer market."