The Dragons are fourth in Group D, only ahead of winless minnows Latvia, and are on a miserable run of form.
Robert Page is under increasing pressure as Wales boss, with his side claiming just one win in the last 13 matches.
Wales have lost their last two qualifiers against Armenia and Turkey and were held by South Korea to a goalless stalemate in a friendly on Thursday.
But victory over 134th-ranked Latvia could move the Euro 2016 semi-finalists up to second behind Turkey, depending on other results.
Latvia vs Wales: talkSPORT coverage
This Euro 2024 qualifier will be played on Thursday, September 7.
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talkSPORT 2 will have live coverage from the Skonto Stadium in Latvia, with kick-off set for 7:45pm.
Commentary will come from Nigel Adderley and former Wales striker Dean Saunders.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
It will also be broadcast live on Viaplay Sports 2 with their coverage starting at 7:35pm.
Latvia vs Wales: Team news
The hosts have several injuries to contend with as Vladislavs Gutkovskis and Raivis Jurkovskis are both sidelined.
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Arturs Zjuzins and Pavels Steinbors have also been forced to withdraw from the squad.
The visitors meanwhile are sweating on the fitness of Chris Mepham after picking up a knock in the friendly with South Korea.
Luton Town captain Tom Lockyer is already missing but Wales skipper Aaron Ramsey is set to start after being benched last time out.
Latvia vs Wales: What has been said?
On recent criticism, Page said: "Everybody's entitled to their opinion.
"It's not a problem. I know what I've got in the changing room and the staff room.
"It's about winning games of football, I get that. But we also have to understand the opposition we're up against. People throw stats about, the transition we're in at the minute. We've lost some world-class senior players.
"We're asking the young players now like JJ to step up and we have to be patient. They're going to make mistakes. They're young players.
"So it's about that development as well."
Latvia vs Wales: Match facts
Should he feature against Latvia, Connor Roberts will be making his 50th international appearance for Wales - under Robert Page, only Joe Rodon and Daniel James (both 31 games) have featured more times for the national team than him (29 games).
Kieffer Moore has been involved in five goals in seven UEFA European Championship qualifiers for Wales (3 goals, 2 assists), including in each of his last two such games against Armenia (1 assist) and the reverse fixture with Latvia in March (1 goal).
Latvia have scored in each of their previous seven home internationals (10 goals), with Janis Ikaunieks one of two players to score more than once during that time (2 - also Roberts Uldrikis).
Wales have failed to score in each of their previous two internationals; only once under Robert Page have they gone three successive games without scoring, doing so between June and September 2021.
Wales have won just one of their last seven away European Championship qualifiers (D2 L4), a 2-0 win at Azerbaijan in November 2019, and are winless in both in this campaign (D1 L1).
Latvia have lost eight of their last nine home European Championship qualifying matches (W1), winning the other 1-0 against Austria in November 2019.
Latvia have lost 11 of their 13 games in all competitions against the British home nations - the other games were victories over Northern Ireland in 1995 (2-1, Euro qualifier) and 2007 (1-0, Euro qualifier).
Wales have won both of their games against Lativa, winning 2-0 in a friendly in August 2004 and 1-0 earlier this year in a European Championship qualifier.