The Yellow Submarine will again be without the services of Vicente Iborra, Juan Foyth and Samuel Chukwueze through injury, but the visitors to the Spanish capital will otherwise be in good shape.
Indeed, both Mario Gaspar and Etienne Capoue are available following suspensions, and the pair are likely to be handed spots in the XI following last weekend's 4-0 win over Sevilla.
Carlos Bacca scored three times against Sevilla and could again lead the line, but there will be changes as head coach Unai Emery prepares for the Europa League final.
Gerard Moreno has been outstanding for the Yellow Submarine this term but could drop down to the bench with one eye on the clash with Man United, meaning that Paco Alcacer may be handed a start.
Manu Trigueros, meanwhile, might be another to be rested, with a three-man midfield potentially including the returning Capoue alongside Dani Parejo and Francis Coquelin.
Villarreal are still fighting for fifth position in the table, though, meaning that a strong side will take to the field, with Pau Torres and Raul Albiol set to operate as the two centre-backs once again.
Villarreal possible starting lineup: Asenjo; Gaspar, Albiol, Torres, Pedraza; Coquelin, Capoue, Parejo; Gomez, Bacca, Alcacer