The Red Devils made it three wins from their three friendlies this summer when they recorded a 2-0 victory over Premier League rivals Arsenal in New Jersey on Saturday evening.
The first team will be back in action against Real Madrid on Wednesday, while a number of youngsters will be involved against Wrexham in San Diego.
Highly-rated forward Charlie McNeill was not included in the first-team squad for the USA tour, as he is believed to be preparing to leave on loan, but the 19-year-old is set to be involved in this match.
Marc Jurado, Isak Hansen-Aaroen, Shola Shoretire and Noam Emeran could also feature, while Radek Vitek, Alvaro Fernandez, Dan Gore and Omari Forson, who are with the first-team squad, may also be involved.
Jonny Evans signed a short-term contract with Man United with a view to featuring in their friendlies against Lyon and Wrexham, so he is also set to take to the field for this match.
There is a slight chance that Hannibal Mejbri could play in central midfield, meanwhile, as he did not feature against Arsenal on Saturday night.
Nathan Bishop will also be hoping to receive some minutes between the sticks, with the Englishman potentially playing the second half of the clash with Wrexham.
Manchester United possible starting lineup: Vitek; Jurado, Evans, Fish, Fernandez; Hannibal, Gore; Forson, Shoretire, Hansen-Aareon; McNeill
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