Andre Onana is available, with the club's number one goalkeeper not expected to link up with the Cameroon squad for the Africa Cup of Nations until after the league game with Tottenham Hotspur next weekend.
The team is expected to be similar to the one that took to the field for the first whistle against Nottingham Forest in the Premier League last time out.
However, the Red Devils will hope to have Rasmus Hojlund back from illness, while Scott McTominay could replace Christian Eriksen in midfield, with Antony also set to drop out of the side.
Man United's injury situation will ease this month, with Luke Shaw, Tyrell Malacia, Lisandro Martinez, Mason Mount, Victor Lindelof, Harry Maguire, Casemiro and Anthony Martial all expected to return in the near future.
Martinez and Casemiro are now back in full training and could potentially be back for the clash with Tottenham at Old Trafford on January 14.
Amad Diallo made his injury return against Forest and is also in contention for more minutes here, while Facundo Pellistri is another option in a wide position.
Hannibal Mejbri and Dan Gore are also both pushing to be involved, although it is likely that the two players will leave Old Trafford on loan before the end of the January market.
Manchester United possible starting lineup: Onana; Wan-Bissaka, Varane, Evans, Dalot; McTominay, Mainoo; Garnacho, Fernandes, Rashford; Hojlund