A youthful Red Devils squad saw off Lyon 1-0 in Edinburgh last time out, where Donny van de Beek struck the only goal of the game four minutes into the second half.
While Ten Hag took a selection of players across the border, several big-name stars such as Casemiro, Christian Eriksen, Bruno Fernandes, Marcus Rashford and Alejandro Garnacho were being put through their paces at Carrington and have now boarded the plane to the USA.
However, Tyrell Malacia and Rhys Bennett are both absent due to injury, while Fred will miss this game due to a personal issue but could join up with the squad at a later date.
Interestingly, Dean Henderson has also made the trip despite intense speculation surrounding his future, and the goalkeeper could act as the last line of defence in New Jersey.
Aaron Wan-Bissaka, Lisandro Martinez and Raphael Varane may feature from the start once more, but Brandon Williams is in with a strong chance of displacing Alvaro Fernandez.
With Fred absent for this game at least, Van de Beek could be a straight swap for his Brazilian counterpart, while Mason Mount and Hannibal Mejbri may complete the engine room if Casemiro and Eriksen are kept in reserve.
The same can be said for Rashford and Garnacho in attack, as Jadon Sancho and Amad Diallo prepare to start out wide again, but Anthony Martial could be given the nod to spearhead the attack.
Manchester United possible starting lineup: Henderson; Wan-Bissaka, Varane, Martinez, Williams; Van de Beek, Hannibal, Mount; Sancho, Martial, Diallo