Only Argentinian attacker Joaquin Correa should be absent as he works his way back from a thigh injury, but Inzaghi has three forwards vying for two spots in his 3-5-2 setup either way.
Having been benched for the weekend's win over Udinese, the fresh legs of Lautaro Martinez should be utilised from the first whistle, leaving Edin Dzeko and Romelu Lukaku to battle it out for the remaining place.
Despite coming up with three goals and an assist in the group stage, Dzeko may just miss out to Lukaku, who ended a 189-day drought without a goal in Serie A against Udinese at the weekend.
Denzel Dumfries and Federico Dimarco - who has created seven chances in Europe this term - will bomb down the flanks, while Nicolo Barella and Marcelo Brozovic are shoo-ins for midfield starts.
Henrikh Mkhitaryan also found the back of the net against Udinese but can expect to make way for Hakan Calhanoglu - the same goes for Matteo Darmian as Milan Skriniar returns to the backline.
The soon-to-be Paris Saint-Germain defender can expect to link arms with Alessandro Bastoni and Francesco Acerbi in front of Andre Onana, who dropped out for Samir Handanovic at the weekend but should be back in goal for the Champions League.
Inter Milan possible starting lineup: Onana; Skriniar, Bastoni, Acerbi; Dumfries, Barella, Calhanoglu, Brozovic, Dimarco; Lukaku, Martinez
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