The teams meet again at San Siro on Tuesday, and six days on from a 2-0 victory in their semi-final opener, Inter will revert to type after making several changes at the weekend.
Preserving his top players for the fifth Milan derby of the season, coach Simone Inzaghi rested Edin Dzeko, Lautaro Martinez, Denzel Dumfries and Andre Onana against Sassuolo, while Romelu Lukaku helped himself to two goals in a 4-2 home win.
The latter's recent revival could now see him challenge Dzeko - who scored the first goal last week - to partner top scorer Martinez up front, but the Belgian striker is more likely to begin the game on the bench.
With Danilo D'Ambrosio and Robin Gosens having returned to fitness, only Paris-bound Milan Skriniar is ruled out by his season-ending back injury.
Set to play a part from the bench after starting on Saturday, Joaquin Correa should overcome a minor knock that saw him replaced at half time to make the squad.
Joining him among the substitutes should be Stefan de Vrij, Raoul Bellanova and Roberto Gagliardini, who alongside club captain Samir Handanovic all started Inter's weekend win - their seventh in succession.
Inter Milan possible starting lineup: Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Martinez, Dzeko