Leeds have been poor in the top-flight so far this season and are without a win in their opening five games.
Fulham lost their last game to an injury-stricken Reading team 2-1 but are still second in the Championship after eight matches.
Leeds saw off Crewe Alexandra in the last round of the cup while Fulham dominated their second round match against Championship counterparts Birmingham.
Fulham v Leeds: talkSPORT commentary
The cup clash will take place on Tuesday, September 21 and will kick-off at 7:45pm.
Commentary will come from Ian Danter and former Leeds and England defender Danny Mills.
To tune in, click HERE for the live stream.
Upcoming talkSPORT commentaries
TUESDAY 21st SEPTEMBER
Norwich v Liverpool - 19:45, Carabao Cup Third Round - talkSPORT
Fulham v Leeds - 19:45, Carabao Cup Third Round - talkSPORT 2
WEDNESDAY 22nd SEPTEMBER
Manchester United v West Ham - 19:45, Carabao Cup Third Round - talkSPORT
Chelsea v Aston Villa - 19:45, Carabao Cup Third Round - talkSPORT 2
FRIDAY 24th SEPTEMBER
West Brom v QPR -20:00, Championship - talkSPORT 2 EXCLUSIVE
SATURDAY 25th SEPTEMBER
Chelsea v Manchester City - 12:30, Premier League - talkSPORT EXCLUSIVE
Manchester United v Aston Villa - 12:30, Premier League - talkSPORT 2 EXCLUSIVE
Everton v Norwich - 15:00, Premier League - talkSPORT 2 EXCLUSIVE
Brentford v Liverpool - 17:30, Premier League - talkSPORT EXCLUSIVE
SUNDAY 26th SEPTEMBER
Manchester United Women v Chelsea Women - 12:30, WSL - talkSPORT 2
Arsenal Women v Manchester City Women - 18:45, WSL - talkSPORT 2
Fulham v Leeds: Confirmed team news
Fulham will be looking to put out a full-strength side after their recent run in the Championship came to an end at the weekend.
The Whites have a couple of long-term injuries with the likes of Kenny Tete and Tom Cairney out.
New signing Nathaniel Chalobah got his first appearance at the weekend and should feature again on Tuesday evening.
Leeds have been plagued with injury worries this season and should be welcoming a return for Diego Llorente and Robin Koch this weekend but the midweek fixture could be too soon for them.
Bielsa was forced to delve into his youth squad on Friday and could be looking to change things up again for the cup match.
Raphinha came off with a knock against Newcastle and the extent of that issue is unconfirmed.
Pascal Struijk won't be available as he will be serving his three-match suspension after his tackle on Harvey Elliott.
Jack Harrison is likely to miss this game after a positive COVID-19 test saw him miss the Newcastle game.