David Moyes' side kicked off Group A with a 3-1 win after coming from behind to avoid a shock defeat against Backa Topola.
The Hammers will now be out to make it two from two, however, they have notoriously struggled in Germany.
Their last three trips to the country have ended in defeat with the most recent coming in the semi-final of this competition against Eintracht Frankfurt in 2022.
This time West Ham take on Freiburg, who also started their group stage off with three points, beating Olympiacos 3-2.
Freiburg vs West Ham: talkSPORT coverage
This Europa League Group A clash will take place on Thursday, October 5.
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Kick-off at the Europa-Park Stadion in Freiburg, Germany is scheduled for 5:45pm UK time.
talkSPORT 2 will have live coverage of the game.
Commentary will come from Alex Crook and former West Ham defender Scott Minto.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
ou can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
The game will also be broadcast live on TNT Sports 2.
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Freiburg vs West Ham: Team news
Freiburg will be missing Yannik Keitel for this clash after he was taken off after only 20 minutes with a knock at the weekend.
However, apart from Keitel's injury, the Germans have no further worries.
As for West Ham, Edson Alvarez will make his European debut for the club after serving a suspension last time out.
Moyes is expected to make some changes from their win against Sheffield United on Saturday, with Mohammed Kudus and Konstantinos Mavropanos coming in to start.
Freiburg vs West Ham: What has been said?
West Ham boss Moyes: "You play games in Europe and, quite often, the Premier League teams are favourites, but you can see that it doesn't always work out that way.
"I'm happy we got off to a good start to the group though.
"We've got difficult games to come against Freiburg and Olympiacos so hopefully this winning start will help us qualify."
Freiburg vs West Ham: Match facts
No player created more chances (7) or provided more assists (2) on MD1 of this season's UEFA Europa League than West Ham's James Ward-Prowse. Indeed, the only English player ever to create more chances in a single match in the competition was Mason Mount for Vitesse v Lazio in November 2017 (8).
Since the start of last season, West Ham have won 15 of their 16 games in European competition (D1), while they have won five of their seven group stage games in the UEFA Europa League overall (D1 L1).
Freiburg are unbeaten in all seven of their UEFA Europa League group stage games since the start of last season (W5 D2), with their last such loss a 0-2 defeat at home to Sevilla in December 2013.
West Ham have lost their last three visits to German sides in European competition, once to Borussia Dortmund (1-3 in April 1966) and twice to Eintracht Frankfurt (1-2 in March 1976, 0-1 in May 2022).
This will be the first ever competitive meeting between Freiburg and West Ham, and the German side's first ever European clash with an English club, the 12th nation Freiburg have faced a side from in UEFA competition.