The 33-year-old, who was a key of part of the Lionesses' success at Euro 2022, has decided to bring the curtain down on an illustrious career in the game.
Having spent more than 17 years in football, White has collected various honours including the Women's Super League (twice), the FA Cup (three times), the WSL Cup (four times) and - most memorably - the UEFA Women's European Championship on home soil.
She bows out with 52 goalsand 113 England caps to her name - an international record for the Three Lions that only Wayne Rooney has bettered for the men's team.
"This has been one of the hardest decisions of my life but one that I know is the right decision for me," said White, as she announced the news on social media with the caption 'Thank You Football…'
"This decision has always been one I have wanted to make on my terms. And this is my time to say goodbye to football and watch the next generation shine.
"It has been my greatest honour and privilege to play this game. In particular playing for England has and always will be the greatest gift.
"My dreams came true on July 31, winning the Euros and becoming a European Champion."
The Lionesses have been determined to capitalise on their success to force change at every sporting level, to boost sporting opportunities for girls and women.
And White urged future England hopefuls never to lose sight of their dreams.
"This is for the next generation and potentially the next Lioness," said White.
"You don't have to be the best at something to make your dreams come true, just look at me.
"Hard work, dedication, passion and love for what you do are a great recipe. Don't ever let someone tell you 'you can't do something or achieve your dreams'.
"I was once told I couldn't play in the boys' team and I would never play for England. Now I am retiring having made 113 caps with 52 goals for England and a European Champion.
"Finally, let's use the momentum from the Euros win to make sure that every young person in all communities has the opportunity to play and feel connected to all England football teams."
Aylesbury-born White began her career began at the age of eight, joining Arsenal, before leaving for Chelsea in 2005.
She became the Blues' top scorer for the three seasons she was there, and joined Leeds United three years later.
Overcoming a cruciate ligament injury, she netted twice in the FA Women's Premier League Cup final against Everton in 2010.
Returning to Arsenal in the same year, she got her hands on several honours in three years. White secured two WSL titles, two FA Cups and three League Cups.
In 2017, whilst playing for Birmingham City, she netted the winning penalty in the semi-finals of the FA Cup against Chelsea and was top scorer in the WSL the following season with 15 goals in 14 matches.
Having moved to Man City in 2019, she added another FA Cup and WSL Cup to her collection and continued her fine scoring record.
England head coach Sarina Wiegman paid tribute to a "world-class" operator, who played a vital role in the Euros triumph.
"Ellen has given so much for England and we are all so proud of her," said Wiegman.
"I have only had the pleasure of working with her for this past year, but her professionalism, work rate and finishing ability is world-class.
"This summer she did an amazing job for the team, she is the perfect team player and helped the younger players to find their way in international football.
"I already knew she was a great player but I found an even better person.
"We will miss her, but I fully understand her decision to take a new direction."